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ALDH2 (8C8) Monoclonal Antibody

Applications

  • WB
  • FCM
  • IHC-P
  • IF

Reactivity

  • Human
Overview
Catalog # bsm-51417M
Product Name ALDH2 (8C8) Monoclonal Antibody
Applications WB, FCM, IHC-P, IF
Reactivity Human
Specifications
Conjugation Unconjugated
Host Mouse
Source This ALDH2 Monoclonal antibody is generated from mouse immunized with ALDH2 recombinant protein.
Clonality Monoclonal
Clone # 8C8
Isotype IgG1
Concentration 0.5ug/ul
Purification Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, followed by dialysis against PBS.
Storage Buffer 0.01M TBS(pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Storage Condition Store at -20°C for 12 months.
Target
Gene ID 217
Swiss Prot P05091
Synonyms ALDM; ALDHI; ALDH-E2; Aldehyde dehydrogenase, mitochondrial; ALDH class 2; ALDH2
Background This protein belongs to the aldehyde dehydrogenase family of proteins. Aldehyde dehydrogenase is the second enzyme of the major oxidative pathway of alcohol metabolism. Two major liver isoforms of this enzyme, cytosolic and mitochondrial, can be distinguished by their electrophoretic mobilities, kinetic properties, and subcellular localizations. Most Caucasians have two major isozymes, while approximately 50% of Orientals have only the cytosolic isozyme, missing the mitochondrial isozyme. A remarkably higher frequency of acute alcohol intoxication among Orientals than among Caucasians could be related to the absence of the mitochondrial isozyme. This gene encodes a mitochondrial isoform, which has a low Km for acetaldehydes, and is localized in mitochondrial matrix.
Application Dilution
WB 1:300-5000
FCM 1:20-100
IHC-P 1:200-400
IF