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MARCH2 Polyclonal Antibody, Biotin Conjugated

Applications

  • WB
  • IHC-P

Reactivity

  • Human
  • Mouse
  • Rat
Overview
Catalog # bs-9336R-Biotin
Product Name MARCH2 Polyclonal Antibody, Biotin Conjugated
Applications WB, IHC-P
Reactivity Human, Mouse, Rat
Specifications
Conjugation Biotin
Host Rabbit
Source KLH conjugated synthetic peptide derived from human MARCH2
Immunogen Range 151-246/246
Clonality Polyclonal
Isotype IgG
Concentration 1ug/ul
Purification Purified by Protein A.
Storage Buffer Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage Condition Store at -20°C for 12 months.
Target
Gene ID 51257
Synonyms E3 ubiquitin protein ligase MARCH2; E3 ubiquitin-protein ligase MARCH2; EC 6.3.2.- antibody HSPC240; MARCH II; MARCH-II; march2; MARH2_HUMAN antibody Membrane associated RING CH protein II; Membrane associated ring finger C3HC4 2; Membrane associated RING finger protein 2; Membrane-associated RING finger protein 2; Membrane-associated RING-CH protein II; RING finger protein 172; RNF172.
Background Ubiquitination is an important mechanism through which three classes of enzymes act in concert to target short-lived or abnormal proteins for destruction. The three classes of enzymes involved in ubiquitination are the ubiquitin-activating enzymes (E1s), the ubiquitin-conjugating enzymes (E2s) and the ubiquitin-protein ligases (E3s). MARCH2 (membrane-associated ring finger (C3HC4) 2), also known as RNF172 or HSPC240, is a 246 amino acid multi-pass membrane protein that localizes to the endoplasmic reticulum and contains one RING-CH-type zinc finger. Expressed in a variety of tissues, MARCH2 functions as an E3 ubiquitin-protein ligase that is thought to mediate the ubiquitination and subsequent degradation of CD71 and B7-2 and may be involved in endosomal protein trafficking.
Application Dilution
WB 1:300-5000
IHC-P 1:200-400