Overview |
bs-9052R-PerCP-Cy5.5 |
DIS3L Polyclonal Antibody, PerCP-Cy5.5 Conjugated |
WB, IF(IHC-P) |
Human, Mouse, Rat |
Specifications |
PerCP-Cy5.5 |
Rabbit |
KLH conjugated synthetic peptide derived from human DIS3L |
701-800/1054 |
Polyclonal |
IgG |
1ug/ul |
Purified by Protein A. |
Aqueous buffered solution containing 0.01M TBS (pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles. |
Target |
115752 |
DIS3 like exonuclease 1; DIS3 mitotic control homolog S. cerevisiae like; FLJ38088; KIAA1955; MGC4562; DI3L1_HUMAN. |
The exosome is a multi-protein complex composed of several highly conserved subunits, some of which are 3? to 5? exoribonucleases. The complex is involved in a variety of cellular processes and is responsible for degrading unstable mRNAs that contain AU-rich elements (AREs) in their untranslated 3? regions. DIS3, also known as RRP44, is a 958 amino acid protein that localizes to both the cytoplasm and the nucleus and contains one PINc domain. Widely expressed with highest expression in testis, DIS3 functions as a component of the exosome exoribonuclease complex and is required for processing of 7S pre-RNA into a mature nuclear complex and, ultimately, for proper mitotic progression. Abnormal expression levels of DIS3 may be associated with colon cancer, suggesting a role for DIS3 in tumorigenesis. Multiple isoforms of DIS3 exist due to alternative splicing events. |
Application Dilution |
WB |
1:300-5000 |
IF(IHC-P) |
1:50-200 |