| Overview |
| bs-8487R-PE |
| FNDC3B Polyclonal Antibody, PE Conjugated |
| WB |
| Human, Mouse, Rat, Dog, Sheep, Pig, Rabbit |
| Specifications |
| PE |
| Rabbit |
| KLH conjugated synthetic peptide derived from human FNDC3B |
| 921-1020/1204 |
| Polyclonal |
| IgG |
| 1ug/ul |
| Purified by Protein A. |
| Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles. |
| Target |
| 64778 |
| Cell membrane |
| Factor for adipocyte dferentiation 104; FAD104; fibronectin type III domain containing 3B; FLJ23399; HCV NS5A binding protein 37; NS5ABP37; YVTM2421; MGC10002; PRO4979; DKFZp686D14170; DKFZp762K137; FND3B_HUMAN. |
| Adipogenesis, the process of transforming pre-adipocytes into mature fat cells, is of particular interest due to the role adipocytes play in obesity and type II diabetes. Adipocytes have been shown to affect a variety of functions, including hemostasis, angiogenesis and energy balance, by secreting hormones and bioactive peptides. The FNDC3B protein, also designated FAD104 (factor for adipocyte differentiation 104) or HCV NS5A-binding protein 37, is expressed during early adipogenesis. Belonging to the FNDC3 family of proteins, FNDC3B is a 1,204 amino acid protein that contains nine fibronectin type-III domains. FNDC3B-deficient mice die within one day of birth, suggesting that FNDC3B is crucial for postpartum survival. Mouse embryonic fibroblasts (MEFs) with loss of FNDC3B function displayed a reduction in stress fiber formation, indicating a role for FNDC3B in cell proliferation, adhesion, spreading and migration. |
| Application Dilution |
| WB |
1:300-5000 |
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