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NFKB1 (Thr931) Polyclonal Antibody, HRP Conjugated

Applications

  • ELISA
  • IHC-P
  • IHC-F

Reactivity

  • Human
  • Rat

Predicted Reactivity

  • Mouse
  • Dog
  • Cow
  • Pig
  • Chicken
Overview
Catalog # bs-5510R-HRP
Product Name NFKB1 (Thr931) Polyclonal Antibody, HRP Conjugated
Applications ELISA, IHC-P, IHC-F
Reactivity Human, Rat
Predicted Reactivity Mouse, Dog, Cow, Pig, Chicken
Specifications
Conjugation HRP
Host Rabbit
Source KLH conjugated Synthesised phosphopeptide derived from human NF KappaB p105 around the phosphorylation site of Thr931
Modification Site Thr931
Clonality Polyclonal
Isotype IgG
Concentration 1ug/ul
Purification Purified by Protein A.
Storage Buffer Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage Condition Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
Target
Gene ID 4790
Swiss Prot P19838
Subcellular location Cytoplasm, Nucleus
Synonyms NFKB1(phospho T931); NFKB1(phospho Thr931); NF kappa B; NFKB 1; NFKB p105; NFKB p50; NFKB1; Nuclear factor kappa B DNA binding subunit; Nuclear factor NF kappa B p105 subunit; Nuclear factor NF kappa B p50 subunit; Nuclear factor of kappa light polypeptide gene enhancer in B cells 1; DKFZp686C01211; DNA binding factor KBF1; DNA binding factor KBF1 EBP1; EBP 1; EBP1; KBF1; MGC54151; nuclear factor of kappa light polypeptide gene enhancer in B-cells 1; Nfkb1; NF-kappaB; NF-kappaB1; NF-KB1; p105; p50; p50/p105; DKFZp686C01211; EBP-1; KBF1; MGC54151; Nf kappa b DNA binding subunit; NF-KAPPAB; NF-KAPPAB1; NFKB; NFKB SUBUNIT P105/P50; NFKB-p105; NFKB1; NUCLEAR FACTOR KAPPA B DNA BINDING SUBUNIT; p105 Nfkb;p50 NF-kappa B;p50NFKB.
Background This gene encodes a 105 kD protein which can undergo cotranslational processing by the 26S proteasome to produce a 50 kD protein. The 105 kD protein is a Rel protein-specific transcription inhibitor and the 50 kD protein is a DNA binding subunit of the NF-kappa-B (NFKB) protein complex. NFKB is a transcription regulator that is activated by various intra- and extra-cellular stimuli such as cytokines, oxidant-free radicals, ultraviolet irradiation, and bacterial or viral products. Activated NFKB translocates into the nucleus and stimulates the expression of genes involved in a wide variety of biological functions. Inappropriate activation of NFKB has been associated with a number of inflammatory diseases while persistent inhibition of NFKB leads to inappropriate immune cell development or delayed cell growth. SUBUNIT: Active NF-kappa-B is a heterodimer of an about 50 kDa DNA-binding subunit and the weak DNA-binding subunit p65. Two heterodimers might form a labile tetramer. Also interacts with MAP3K8. NF-kappa-B p50 subunit interacts with NCOA3 coactivator, which may coactivate NF-kappa-B dependent expression via its histone acetyltransferase activity. Interacts with DSIPI; this interaction prevents nuclear translocation and DNA-binding. Interacts with SPAG9 and UNC5CL.
Application Dilution
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500