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ICOS/CD278 Polyclonal Antibody, APC Conjugated

Applications

  • WB
  • IF(IHC-P)
  • IF(IHC-F)
  • IF(ICC)

Reactivity

  • Human

Predicted Reactivity

  • Mouse
  • Rat
  • Pig
Overview
Catalog # bs-2583R-APC
Product Name ICOS/CD278 Polyclonal Antibody, APC Conjugated
Applications WB, IF(IHC-P), IF(IHC-F), IF(ICC)
Specificity This antibody may also have a secondary cross-reactivity with AP-1 complex-associated regulatory protein due to a 77% non-contiguous sequence similarity in the corresponding immunogen region.
Reactivity Human
Predicted Reactivity Mouse, Rat, Pig
Specifications
Conjugation APC
Host Rabbit
Source KLH conjugated synthetic peptide derived from human ICOS
Immunogen Range 51-150/199
Clonality Polyclonal
Isotype IgG
Concentration 1ug/ul
Purification Purified by Protein A.
Storage Buffer Aqueous buffered solution containing 0.01M TBS (pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage Condition Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
Target
Gene ID 29851
Swiss Prot Q9Y6W8
Subcellular location Secreted, Cell membrane
Synonyms AILIM; CD278; CVID1; Inducible T-cell costimulator; Activation-inducible lymphocyte immunomediatory molecule; ICOS
Background Enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines, up-regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B-cells. Essential both for efficient interaction between T and B-cells and for normal antibody responses to T-cell dependent antigens. Does not up-regulate the production of interleukin-2, but superinduces the synthesis of interleukin-10. Prevents the apoptosis of pre-activated T-cells. Plays a critical role in CD40-mediated class switching of immunoglobin isotypes (By similarity).
Application Dilution
WB 1:300-5000
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200