| Overview |
| bs-24450R-BF680 |
| Polycystin 2 Polyclonal Antibody, AbBy Fluor® 680 Conjugated |
| WB |
| Human |
| Mouse, Rat, Cow, Pig, Horse, Rabbit, Zebrafish |
| Specifications |
| AbBy Fluor® 680 |
| Rabbit |
| KLH conjugated synthetic peptide derived from human Polycystin 2 |
| 41-140/968 |
| Polyclonal |
| IgG |
| 1ug/ul |
| Purified by Protein A. |
| Aqueous buffered solution containing 0.01M TBS (pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles. |
| Target |
| 5311 |
| Q13563 |
| Cytoplasm, Cell membrane |
| polycystic kidney disease 2; TRPP2; APKD2, C030034P18RIK, MGC138466, MGC138468, PC2, PKD2 (includes EG:5311), PKD4, POLYCISTIN-2, POLYCYSTIN 2, RGD1559992, TRPP2; Polycystic kidney disease 2 protein homolog; PC2. |
| Involved in fluid-flow mechanosensation by the primary cilium in renal epithelium. PKD1 and PKD2 may function through a common signaling pathway that is necessary for normal tubulogenesis. Acts as a regulator of cilium length, together with PKD1. The dynamic control of cilium length is essential in the regulation of mechanotransductive signaling. The cilium length response creates a negative feedback loop whereby fluid shear-mediated deflection of the primary cilium, which decreases intracellular cAMP, leads to cilium shortening and thus decreases flow-induced signaling. Functions as a calcium permeable cation channel. |
| Application Dilution |
| WB |
1:300-5000 |
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