Fludarabine
| Overview | |
| Catalog # | bs-83082c-10-mg |
| Product Name | Fludarabine |
| Specifications | |
| Storage Buffer | Colorless to pale yellow oil |
| Storage Condition | -20°C |
| Target | |
| Product Information | A synthetic adenosine analog that inhibits DNA biosynthesis and is a clinically useful antineoplastic agent.1 In cells fludarabine accumulates as its 5’-triphosphate (F-ara-ATP) for which the rate-limiting step in formation is the conversion of fludarabine to its monophosphate.2 F-ara-ATP has multiple mechanisms of action including inhibition of ribonucleotide reductase, DNA polymerase, ligase and primase.2 A frequently used agent in myeloablative conditioning regimens for allogeneic hematopoietic cell transplantation.3 Immunosuppressive effects are mediated via inhibition of TNF-stimulated production of IL-2 and IFN- through inactivation of NFB.4 Antagonist at adenosine A1 receptors.5 |
| Description | CAS Number: 21679-14-1 Chemical Name: 9-β-D-Arabinofuranosyl-2-fluoro-9H-purin-6-amine; Molecular weight: 285.23 Formula: C10H12FN5O4 Solubility: DMSO (30 mg/ml) Physical Properties: White solid Purity: 98% by HPLC NMR (Conforms) |
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