TASIN-1
| Overview | |
| Catalog # | bs-83054c-5-mg |
| Product Name | TASIN-1 |
| Specifications | |
| Storage Buffer | White solid |
| Storage Condition | -20°C |
| Target | |
| Product Information | Selectively induces apoptosis in cells with truncations in the adenomatous polyposis coli (APC) gene (but not normal cells or wild type cancer cells), an important multifunctional tumor suppressor gene.1 IC50 = 70nM for DLD1 cell line. It inhibited cancer cell growth in human tumor xenografts (DLD1 and HT29 tumors) and a genetically engineered mouse model (CPC;Apc) of colorectal cancer. TASIN-1 induces ER stress-dependent JNK activation with ROS production and AKT inhibition via cholesterol depletion.2 |
| Description | CAS Number: 1678515-13-3 Chemical Name: 1-[1-(4-Methoxyphenyl)sulfonylpiperidin-4-yl]-4-methylpiperidine hydrochloride Molecular weight: 388.95 Formula: C18H28N2O3S·HCl Solubility: DMSO (20 mg/ml) Physical Properties: White or off-white solid Purity: 98% by HPLC NMR (Conforms) |
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