MK-2206
| Overview | |
| Catalog # | bs-83025c-5-mg |
| Product Name | MK-2206 |
| Specifications | |
| Storage Buffer | Pale yellow solid |
| Storage Condition | -20°C |
| Target | |
| Product Information | MK-2206 is a potent and selective allosteric inhibitor of Akt (IC50’s: Akt1 = 5 nM, Akt2 = 12 nM, Akt3 = 65 nM) that enhances the in vitro and in vivo antitumor efficacy of several standard chemotherapeutic agents.1 It was able to decrease insulin-stimulated glucose uptake, glycogen synthesis and glycogen synthase activity in rat muscle.2 MK-2206 induced G1-phase cycle arrest and sensitized HepG2 hepatocellular carcinoma cells to TRAIL-induced apoptosis.3 |
| Description | CAS Number: 1032350-13-2 Chemical Name: 8-(4-(1-Aminocyclobutyl)phenyl-9-phenyl-2H-[1,2,4]triazolo[3,4-f][1,6]naphthyridin-3-one dihydrochloride Molecular weight: 480.39 Formula: C25H21N5O·2HCl Solubility: DMSO (10 mg/ml) Physical Properties: Yellow solid Purity: 98% by HPLC, NMR (Conforms) |
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