LDN-193189 HCl
| Overview | |
| Catalog # | bs-83010c-5-mg |
| Product Name | LDN-193189 HCl |
| Specifications | |
| Storage Buffer | White solid |
| Storage Condition | -20°C |
| Target | |
| Product Information | LDN-193189 HCl is a potent and selective inhibitor of ALK2 (IC50 = 5 nM) and ALK3 (IC50 = 30 nM), thereby inhibiting SMAD1/5/8 phosphorylation.1 Only weak inhibition of ALK4, ALK5, and ALK7 is observed. Promotes neuronal differentiation of human pluripotent stem cells.2-3 LDN-193189 HCl has also been used to examine the role of osteogenesis in prostate tumor metastases in bone.4 |
| Description | CAS Number: 1062368-62-0 Chemical Name: 4-[6-[4-(1-Piperazinyl)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]-quinoline hydrochloride Molecular weight: 479.4 Formula: C25H22N6·2HCl Solubility: DMSO or Water (up to 5 mg/ml) Physical Properties: Orange-yellow solid Purity: 99% by HPLC (Agilent Poroshell 120 C18, 80/20 MeOH/water with 0.05% TFA; 0.8 ml/min) NMR (Conforms) |
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