GSK8612

Overview
Catalog #	bs-82992c-5-mg
Product Name	GSK8612
Specifications
Storage Buffer	Off-white solid
Storage Condition	-20°C
Target
Product Information	Highly selective and potent (avg. pIC50 = 6.8 versus recombinant TBK1) inhibitor of Tank-binding Kinase-1 (TBK1) with higher affinity for unactivated TBK1. It inhibited phosphorylation of IRF3 (pIC50 = 6.0), inhibited the release of IFNa from human PBMC’s (pIC50 = 6.1), and inhibited IFNb secretion from THP-1 cells (pIC50 = 5.8 dsDNA virus, 6.3 cGAMP stilmulated cells).
Description	CAS Number: 2361659-62-1 Chemical Name: 4-[[[5-Bromo-2-[[3-methyl-1-(2,2,2-trifluoroethyl)pyrazol-4-yl]amino]pyrimidin-4-yl]amino]methyl]benzenesulfonamide Molecular weight: 520.33 Formula: C17H17BrF3N7O2S Solubility: Soluble in DMSO (20 mg/ml) Physical Properties: Beige solid Purity: 98% by HPLC NMR (Conforms)