PF-670462 dihydrochloride

Overview
Catalog #	bs-82991c-5-mg
Product Name	PF-670462 dihydrochloride
Specifications
Storage Buffer	Beige solid
Storage Condition	-20°C
Target
Product Information	Potent inhibitor of casein kinase 1ε/δ (CK1ε, IC50 = 7.7 nM; CK1δ, IC50 = 14 nM).1 It is a circadian clock modifier that caused robust phase delays in rats1 and Cynomolgus monkeys2. PF-670462 caused nuclear retention of the clock protein PER resulting in period lengthening in a phase-specific manner that was dependent on CK1δ inhibition and not CK1ε.3 It improved cognitive performance and reduced amyloid load in various mouse models of Alzheimer’s disease.4-6 PF-670462 slowed the progression of and increased survival of chronic lymphocytic leukemia in mice alone and in combination with Ibrutinib.7
Description	CAS Number: 950912-80-8 Chemical Name: 4-[3-Cyclohexyl-5-(4-fluorophenyl)imidazol-4-yl]pyrimidin-2-amine 2HCl Molecular weight: 337.4 Formula: C19H22Cl2FN5 Solubility: DMSO (25 mg/ml) Physical Properties: Off-white solid Purity: >98% by HPLC, NMR (Conforms)