Necrostatin-34

Overview
Catalog #	bs-82988c-5-mg
Product Name	Necrostatin-34
Specifications
Storage Buffer	Off-white solid
Storage Condition	-20°C
Target
Product Information	Necrostatin-34 is a selective inhibitor of RIP1 kinase. IC50s = 667 nM and 134 nM for TNFα in FAD-deficient Jurkat cells and L929 cells respectively. It binds to a site distinct from that of 7-Cl-O-Nec1 (Focus Cat# 10-4544) locking the enzyme in an inactive conformation. Necrostatin-34 acts synergistically with 7-Cl-O-Nec1 to inhibit necroptosis.
Description	CAS Number: 375835-43-1 Chemical Name: 2-[[5-Cyano-4-(4-methylphenyl)-2-oxo-3,4-dihydro-1H-pyridin-6-yl]sulfanyl]-N-(1,3-thiazol-2-yl)acetamide Molecular weight: 384.47 Formula: C18H16N4O2S2 Solubility: DMSO (>25 mg/ml) Physical Properties: Off-white solid Purity: >98% by HPLC NMR (Conforms)