Clodronate 2Na
| Overview | |
| Catalog # | bs-82959c-10-mg |
| Product Name | Clodronate 2Na |
| Specifications | |
| Storage Buffer | White solid |
| Storage Condition | -20°C |
| Target | |
| Product Information | Clodronate is a first generation non-nitrogenous bisphosphonate drug for the prevention and treatment of osteoporosis and skeletal fractures/hypercalcemia in patients with cancer. It strongly binds to hydroxyapatite and directly reduces osteoclast activity.1 Clodronate is metabolized in vitro to a cytotoxic ATP analog (AppCCl2p) which inhibits ADP/ATP translocase in the mitochondrial inner membrane leading to osteoclast apoptosis.2 |
| Description | CAS Number: 88416-50-6 Chemical Name: Dichloromethylenediphosphonic acid disodium tetrahydrate Molecular weight: 360.92 Formula: CH2Cl2O6P2·2Na·4H2O Solubility: Water (>10 mg/ml) Physical Properties: White solid Purity: 98%, NMR (Conforms) |
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