FPS-ZM1

Overview
Catalog #	bs-82952c-10-mg
Product Name	FPS-ZM1
Specifications
Storage Buffer	White solid
Storage Condition	-20°C
Target
Product Information	FPS-ZM1 is a high-affinity Receptor for Advanced Glycation End products (RAGE) inhibitor (IC50 = 0.6 μM). It is able to lower levels of Aβ via binding to the V domain of RAGE and can block multiple mechanisms of Aβ40- and Aβ42-induced cellular stress in RAGE-expressing brain endothelium, neurons and microglia in vitro and in vivo.1,2 Can cross the BBB. In a rat model of intracerebral hemorrhage, FPS-ZM1 was able to attenuate blood-brain barrier and white matter fiber damage.3 FPS-ZM1 inhibition of RAGE was able to ameliorate inflammatory damage after acute intracerebral hemorrhage via downstream blockade of high mobility box-1(HMGB1) signaling.4 FPS-ZM1 has also been shown to impair breast cancer cell invasion and metastasis.5
Description	CAS Number: 945714-67-0 Chemical Name: 4-Chloro-N-cyclohexyl-N-(phenylmethyl)benzamide Molecular weight: 327.85 Formula: C20H22ClNO Solubility: DMSO (35 mg/ml) Ethanol (20 mg/ml) Physical Properties: Off-White solid Purity: 98% by HPLC, NMR (Conforms)