PFK15

Overview
Catalog #	bs-82933c-5-mg
Product Name	PFK15
Specifications
Storage Buffer	White solid
Storage Condition	-20°C
Target
Product Information	PFK15 is an inhibitor of the metabolic enzyme 6-Phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 (PFKFB3). PFKFB3 is constitutively expressed by neoplastic cells and is required for the high glycolytic rate (Warburg Effect) of these cells. PFK15 inhibits PFKFB3 (IC50 = 207 nM) without inhibiting 96 other kinases.1 PFK15 was able to potently inhibit glucose and F26BP uptake. It induced apoptosis and reduced tumor growth in vitro and in vivo. PFK15 has been shown to inhibit tumor growth in various cancer models.2,3
Description	CAS Number: 4382-63-2 Chemical Name: 1-(4-Pyridinyl)-3-(2-quinolinyl)-2-propen-1-one Molecular weight: 260.29 Formula: C17H12N2O Solubility: DMSO (15 mg/ml) Ethanol (5 mg/ml) Physical Properties: Pale yellow solid Purity: 99% by HPLC, NMR (Conforms)