NHI-2

Overview
Catalog #	bs-82918c-10-mg
Product Name	NHI-2
Specifications
Storage Buffer	White solid
Storage Condition	-20°C
Target
Product Information	NHI-2 is a selective inhibitor of Lactate Dehydrogenase A (LDHA) – IC50 in vitro = 14.7 µM (NADH), 10.5 µM (Pyruvate).1 NHI-2 has also shown cellular growth inhibitory effects against pancreatic cancer cells (PANC-1 cells IC50 = 22.2 µM normoxic and 4.0 µM hypoxic; LPC006 cells IC50 = 17.8 µM normoxic and 1.1 µM hypoxic) with increased efficacy in a cancer cells hypoxic environment.2 LDHA is a key enzyme involved in the Warburg effect and a cancer cells ability to survive in a hypoxic environment.
Description	CAS Number: 1269802-97-2 Chemical Name: Methyl 1-Hydroxy-6-phenyl-4-trifluoromethyl-1H-indole-2-carboxylate Molecular weight: 335.28 Formula: C17H12F3NO3 Solubility: DMSO (25 mg/ml) Ethanol (25 mg/ml) Physical Properties: Off-white solid Purity: 98% by HPLC, NMR (Confirms)