Tubastatin A · HCl

Overview
Catalog #	bs-82899c-5-mg
Product Name	Tubastatin A · HCl
Specifications
Storage Buffer	White solid
Storage Condition	-20°C
Target
Product Information	Tubastatin A is a potent and highly selective inhibitor of HDAC6 (IC50 = 15 nM, >1000-fold selectivity against other HDAC isoforms, approx. 60-fold versus HDAC8).1 It displayed anti-inflammatory and anti-rheumatic effects in Freund’s competitive adjuvant induced animal model of inflammation.2 Tubastatin A inhibited TNF-α (IC50 = 272 nM) and IL-6 (IC50 = 712 nM) in LPS stimulated human THP-1 macrophages.2 Tubastatin A has also been shown to have therapeutic potential for treatment of Alzheimers disease via altered amloid-β load and reduced tau hyperphosphorylation.3,4,5
Description	CAS Number: 1310693-92-5 Chemical Name: N-Hydroxy-4-[(2-methyl-3,4-dihydro-1H-pyrido[4,3-b]indol-5-yl)methyl]benzamide hydrochloride Molecular weight: 371.86 Formula: C20H22N3O2 · HCl Solubility: DMSO or water Physical Properties: solid Purity: 99% by HPLC, NMR (Conforms)