Salubrinal

Overview
Catalog #	bs-82890c-5-mg
Product Name	Salubrinal
Specifications
Storage Buffer	White solid
Storage Condition	-20°C
Target
Product Information	Endoplasmic reticulum (ER) stress inhibitor. Salubrinal is a selective inhibitor of cellular complexes that dephosphorylate eukaryotic initiation factor 2 subunit alpha (eIF2α).1 It has been found to interact with the anti-apoptotic protein Bcl-2 offering protection from the apoptotic and autophagic effects that result from loss of Bcl-2 function.2 Salubrinal blocked NFATc1 expression and osteoclast differentiation by RANKL via phosphorylation of eLF2α resulting in a decrease of global protein synthesis. It efficiently blocked osteoporosis in a mouse model treated with RANKL.3
Description	CAS Number: 405060-95-9 Chemical Name: 3-Phenyl-N-[2,2,2-trichloro-1-[[(8-quinolinylamino)thioxomethyl]amino]ethyl]-2-propenamide Molecular weight: 479.81 Formula: C21 H17 Cl3 N4 O S Solubility: DMSO (25 mg/ml) Physical Properties: Beige solid Purity: 98% by TLC [1% methanol in methylene chloride Rf = 0.35], NMR (Conforms)