PF-06840003

Overview
Catalog #	bs-82880c-10-mg
Product Name	PF-06840003
Specifications
Storage Buffer	White solid
Storage Condition	-20°C
Target
Product Information	PF-06840003 (198474-05-4) is a potent (IC50 = 150 and 410 nM via two methods) and selective inhibitor of Indoleamine-2,3-dioxygenase (IDO1).1 In mice with syngeneic tumor grafts, it reduced intratumoral kynurenine levels by over 80%, inhibited tumor growth as monotherapy, and increased the efficacy of anti-PD-L1 therapy.2 PF-06840003 treatment combined with GM-CSF-secreting allogenic pancreatic tumor cell vaccine (GVAX) resulted in increased antitumor efficacy in a murine model of pancreatic ductal adenocarcinoma.3
Description	CAS Number: 198474-05-4 Chemical Name: 3-(5-Fluoro-1H-indol-3-yl)pyrrolidine-2,5-dione Molecular weight: 232.21 Formula: C12H9FN2O2 Solubility: DMSO (>25 mg/ml) Physical Properties: White solid Purity: 98% by TLC NMR (Conforms)