Ganetespib

Overview
Catalog #	bs-82873c-5-mg
Product Name	Ganetespib
Specifications
Storage Buffer	Off-white or white solid
Storage Condition	-20°C
Target
Product Information	Ganetespib is an inhibitor of heat shock protein 90 (IC50 = 19 nM, canine C2 malignant mast cells; 4 nM, canine BR malignant mast cells) binding to the N-terminal ATP site.1 It displayed potent cytotoxicity against a panel of 57 transformed cell lines of both hematologic and solid tumors with IC50’s between 14 and 280 nM.2 Ganetespib enhanced T-cell-mediated killing of human melanoma cells and potentiated responses to anti-CTLA4 and anti-PD1 therapy via upregulation of interferon response genes.3 In multiple clinical trials for various cancers.
Description	CAS Number: 888216-25-9 Chemical Name: 3-(2,4-Dihydroxy-5-propan-2-ylphenyl)-4-(1-methylindol-5-yl)-1H-1,2,4-triazol-5-one Molecular weight: 364.40 Formula: C20H20N4O3 Solubility: DMSO (>25 mg/ml) Physical Properties: White solid Purity: 98% by HPLC NMR (Conforms)