SBI-553

Overview
Catalog #	bs-82868c-5-mg
Product Name	SBI-553
Specifications
Storage Buffer	Pale yellow solid
Storage Condition	-20°C
Target
Product Information	SBI-553 is a potent, brain penetrant, and orally bioavailable allosteric modulator of neurotensin receptor 1 (NTSR1; EC50 = 340 nM)).1 It acts as a ß-Arrestin-biased agonist and selectively antagonizes G protein signaling conferring profound ß-Arrestin bias towards the endogenous ligand.2,3 SBI-553 displayed efficacy in mouse models of psychostimulant abuse without the characteristic undesirable side effects of unbiased NTSR1 agonism. This functionally selective modulation of NTSR1 may be a new therapeutic approach to treating psychostimulant abuse and other chemical and behavioral addictions.
Description	CAS Number: 1849603-72-0 Chemical Name: 2-[[2-(1-Fluorocyclopropyl)-4-[4-(2-methoxyphenyl)piperidin-1-yl)quinazolin-6-yl]methylamino]ethanol Molecular weight: 450.56 Formula: C26H31FN4O2 Solubility: DMSO (12 mg/ml) Physical Properties: Pale yellow solid Purity: >98% by HPLC NMR (conforms)