Ki8751

Overview
Catalog #	bs-82853c-5-mg
Product Name	Ki8751
Specifications
Storage Buffer	Off white or beige solid
Storage Condition	-20°C
Target
Product Information	Very potent (IC50 = 0.9 nM) inhibitor of vascular endothelial growth factor receptor 2 (VEGFR-2).1 It also inhibited PDGFRα (IC50 = 67 nM), c-Kit (IC50 = 40 nM), and FGFR2 (IC50 = 170 nM). Ki8751 completely suppressed HUVEC growth at 1 nM. Ki8751 completely inhibited tumor growth in LC-6 human tumor xenografts @ 5mg/kg. Ki8751 displayed anti-influenza A and B activity via disruption of virus entry in a PDGFRß/GM3-dependent manner.2
Description	CAS Number: 228559-41-9 Chemical Name: N-(2,4-Difluorophenyl)-N’-[4-[(6,7-dimethoxy-4-quinolinyl)oxy]-2-fluorophenyl]urea Molecular weight: 469.42 Formula: C24H18F3N3O4 Solubility: DMSO (15 mg/ml) Physical Properties: White solid Purity: >98% by HPLC NMR (Conforms)