Divin

Overview
Catalog #	bs-82794c-5-mg
Product Name	Divin
Specifications
Storage Buffer	White solid
Storage Condition	-20°C
Target
Product Information	Divin is an iron, cobalt, and copper chelator that arrests the late stages of cytokinesis in bacteria by blocking the physical process of constriction in dividing cells without affecting FtsZ. Iron starvation leads to transcriptional down-regulation of genes encoding proteins involved in cell division and affects the spatiotemporal localization of the divisome. Long-term treatment of bacteria with Divin resulted in cellular damage and prevented reactivation of the divisome even in the presence of iron-replete conditions. Iron deprivation is a potential adjuvant therapy for treating bacterial antibiotic resistance.
Description	CAS Number: 1443321-11-6 Chemical Name: N’-[(E)-(2-Hydroxynaphthalen-1-yl)methylidene]-3-(2-methyl-1H-benzimidazol-1-yl)propanehydrazide Molecular weight: 372.42 Formula: C22H20N4O2 Solubility: DMSO (>25 mg/ml) Physical Properties: Pale yellow solid Purity: 98% by HPLC NMR (Conforms)