ML277

Overview
Catalog #	bs-82785c-5-mg
Product Name	ML277
Specifications
Storage Buffer	White solid
Storage Condition	-20°C
Target
Product Information	ML277 is a potent (EC50 = 260 nM) activator of Kv7.1 with selectivity against Kv7.2, Kv7.4, and Kv11.1 (hERG).1 ML277 enhances cardiac delayed rectifier K+ currents (IKs) in human iPSC-derived cardiomyocytes from normal and long QT-interval syndrome afflicted patients suggesting potential therapeutic use in long QT-interval syndrome.2,3 It displayed cardioprotective effects against ischemia in cellular and whole-heart models.4
Description	CAS Number: 1401242-74-7 Chemical Name: (2R)-N-[4-(4-Methoxyphenyl)-2-thiazolyl]-1-[(4-methylphenyl)(sulfonyl]-2-piperidinecarboxamide Molecular weight: 471.59 Formula: C23H25N3O4S2 Solubility: DMSO (20 mg/ml) Physical Properties: White solid Purity: >98% by HPLC NMR (Conforms)