GSK2879552

Overview
Catalog #	bs-82762c-5-mg
Product Name	GSK2879552
Specifications
Storage Buffer	White solid
Storage Condition	-20°C
Target
Product Information	GSK289552 is potent, selective, and irreversible inhibitor of Lysine Demethylase 1 (LSD1) via covalent modification of the LSD1 cofactor FAD (Ki = 1.7 µM). It is selective for LSD1 over the closely related LSD2, MAO-A, MAO-B, and the FAD dependent enzymes D-amino acid oxidase and glutathione reductase. Tested against a panel of 165 cancer cell lines, GSK2879552 inhibited the proliferation of 9 small cell lung carcinoma lines and 20 AML cell lines.
Description	CAS Number: 1401966-69-5 (free base) Chemical Name: 4-[[4-[[[(1R,2S)-2-Phenylcyclopropyl]amino]methyl]-1-piperidinyl]methyl]benzoic acid dihydrochloride Molecular weight: 437.40 Formula: C23H28N2O2 ·2HCl Solubility: DMSO (25 mg/ml) Water (>25 mg/ml) Physical Properties: White solid Purity: 98% by HPLC NMR (Conforms)