SB-705498

Overview
Catalog #	bs-82744c-5-mg
Product Name	SB-705498
Specifications
Storage Buffer	White solid
Storage Condition	-20°C
Target
Product Information	Potent and selective antagonist of the TRPV1 receptor (IC50’s for receptor induction method: Capsaicin = 3 nM; Acid (pH5.3) = pIC50 7.1, and Heat = 6 nM) with activity in human, rat, and guinea pig receptors.1,2 SB-705498s activity is voltage dependent and shows >100 fold selectivity over the closely related TRPM8 receptor.2
Description	CAS Number: 501951-42-4 Chemical Name: 1-(2-Bromophenyl)-3-[(3R)-1-[5-(trifluoromethyl)pyridine-2-yl]pyrrolidine-3-yl]urea Molecular weight: 429.24 Formula: C17H16BrF3N4O Solubility: DMSO (>25 mg/ml) Physical Properties: White solid Purity: 98% by HPLC , NMR (Conforms)