E7820

Overview
Catalog #	bs-82735c-5-mg
Product Name	E7820
Specifications
Storage Buffer	White solid
Storage Condition	-20°C
Target
Product Information	E7820 is an angiogenesis inhibitor that suppresses expression of integrins α2, α3, α5, and ß1.1 Broad-spectrum antitumor and antiangiogenic effects are mainly mediated via integrin α2 suppression.2 E7820 has been identified as a molecular glue that induces proteasomal degradation of the U2AF-related splicing factor CAPERα (RBM39) via CRL4DCAF15 mediated ubiquitination in human cancer cell lines.3,4 E7820 has also been shown to induce degradation of the aryl hydrocarbon receptor nuclear translator (ARNT), a protein essential in maintaining cellular homeostasis in response to environmental stress.5
Description	CAS Number: 289483-69-8 Chemical Name: N-(3-Cyano-4-methyl-1H-indol-7-yl)-3-cyanobenzenesulfonamide Molecular weight: 336.37 Formula: C17H12N4O2S Solubility: DMSO (>25 mg/ml) Physical Properties: White solid Purity: 98% by HPLC , NMR (Conforms)