Elafibranor

Overview
Catalog #	bs-82719c-5-mg
Product Name	Elafibranor
Specifications
Storage Buffer	Orange solid
Storage Condition	-20°C
Target
Product Information	Elafibranor is a dual PPARalpha/delta agonist (EC50 PPARalpha = 10-20 nM; PPARdelta = 100-150 nM).1 It was able to decrease plasma triglycerides levels1, increase HDL cholesterol levels in human studies1, and improve hepatic and peripheral insulin sensitivity2. Elafibranor’s antidiabetic effects in db/db were without the adverse cardiac effects seen in PPARgamma agonism.3 Elafibranor has also been shown to have therapeutic promise in the treatment of nonalcoholic steatohepatitis (NASH).4-6
Description	CAS Number: 923978-27-2 Chemical Name: 2-[2,6-Dimethyl-4-[(E)-3-(4-methylsulfanylphenyl)-3-oxoprop-1-enyl]phenoxy]-2-methylpropanoic acid Molecular weight: 384.49 Formula: C22H24O4S Solubility: DMSO (>25 mg/ml) Physical Properties: Pale yellow solid Purity: 98% by HPLC NMr (Conforms)