IMR-1

Overview
Catalog #	bs-82696c-5-mg
Product Name	IMR-1
Specifications
Storage Buffer	Viscous oil
Storage Condition	-20°C
Target
Product Information	Inhibitor of Mastermind Recruitment-1 (IMR-1) disrupts the recruitment of Mastermind-like 1 to the Notch transcriptional activation complex (NTC) on chromatin, which attenuates Notch target gene transcription1. IC50=26 M (in vitro assay). IMR-1 inhibits the growth of Notch-dependent cell lines and attenuates the growth of patient-derived tumor xenografts. The ethylester is hydrolyzed by intracellular esterases which produces the free acid compound (IMR-1A), IC50=0.5 M (in vitro assay). Binding of IMR-1 to NTC is non-covalent and reversible.1
Description	CAS Number: 310456-65-6 Chemical Name: 2-[2-Methoxy-4-[(4-oxo-2-thioxo-5-thiazolidinylidene)methyl]phenoxy]-acetic acid ethyl ester Molecular weight: 353.41 Formula: C15H15NO5S2 Solubility: DMSO (45 mg/ml) Ethanol (9 mg/ml) Physical Properties: Yellow solid Purity: 98% by TLC NMR (Conforms)