CPI-613

Overview
Catalog #	bs-82689c-5-mg
Product Name	CPI-613
Specifications
Storage Buffer	White solid
Storage Condition	-20°C
Target
Product Information	Lipoic acid analog which potently disrupts mitochondrial metabolism with selectivity for tumor cells in vitro and shows strong antitumor activity in vivo.1 Inhibits alpha-ketoglutarate dehydrogenase (KGDH) by a redox mechanisms selectively in tumor cells.2 Inhibits pyruvate dehydrogenase (PDH) as a mechanistically distinct, non-redox, effect.1,2 A novel anticancer agent with a mitochondria-targeted mode of action with non-genotoxic propertie.3. Has been used (along with PS48) to induce a Warburg-like metabolic state in fibroblasts.4 Combination treatment of CPI-613 and chloroquine inhibits the progression of clear cell sarcoma in a mouse model.5
Description	CAS Number: 95809-78-2 Chemical Name: 6,8-bis(benzylthio-octanoic acid); Molecular weight: 388.59 Formula: C22H28O2S2 Solubility: DMSO (30 mg/ml) Ethanol (20 mg/ml) Physical Properties: White solid Purity: 98% by TLC NMR (Conforms)