Streptonigrin
Overview | |
Catalog # | bs-82684c-1-mg |
Product Name | Streptonigrin |
Specifications | |
Storage Buffer | Off-white solid |
Storage Condition | -20°C |
Target | |
Product Information | Streptonigrin promotes heterochromatin formation at concentrations as low as 1 nM, a concentration at which there was no effect on proliferation or viability.1 Inhibits the SUMO-specific protease SENP1 resulting in increased global SUMOylation levels and reduced level of HIF1α.2 Stabilizes p53 via inhibition of transglutaminase 2 resulting in p53-mediated apoptosis in renal cell carcinoma cells.3 Cytotoxic to fast-cycling melanoma cells but leaves a small population of slow-dividing cells unaffected and may be considered a tool to enrich cultures with cells exhibiting melanoma stem cell characteristics.4 |
Description | CAS Number: 3930-19-6 Chemical Name: Fermentation product from Streptomyces flocculus Molecular weight: 506.47 Formula: C25H22N4O8 Solubility: DMSO Physical Properties: Black solid Purity: >95% HPLC, NMR (Conforms) |