Autophinib

Overview
Catalog #	bs-82683c-5-mg
Product Name	Autophinib
Specifications
Storage Buffer	White solid
Storage Condition	-20°C
Target
Product Information	Inhibits autophagy induced by starvation or rapamycin by inhibiting the lipid kinase VPS34 (IC50=19 nM).1 Increased autophagy and apoptosis were rescued by autophinib in Per1-overexpressing oral squamous cell carcinoma cells.2 Autophinib has quickly become an important biochemical tool for inhibition of autophagy in a variety of cellular contexts.3-5
Description	CAS Number: 1644443-47-9 Chemical Name: 6-Chloro-N-(5-methyl-1H-pyrazol-3-yl)-2-(4-nitrophenoxy)-4-pyrimidinamine Molecular weight: 346.73 Formula: C14H11ClN6O3 Solubility: DMSO (30 mg/ml) Physical Properties: Off-white solid Purity: >98% by HPLC NMR (Conforms)