VGX1027

Overview
Catalog #	bs-82675c-5-mg
Product Name	VGX1027
Specifications
Storage Buffer	White solid
Storage Condition	-20°C
Target
Product Information	Immunomodulator. Inhibits secretion of IL-1β, TNF-α, and IL-10 from murine macrophages stimulated with LPS and spares T cell function.1 Ameliorates the course of acute and chronic immunoinflammatory conditions such as carrageenan-induced pleurisy, LPS-induced lethality and type II collagen-induced arthritis in mouse models.1 Prevents spontaneous and accelerated forms of autoimmune diabetes in a NOD mouse model.2 Moldulates genes involved in LPS-induced Toll-like receptor 4 activation in a mouse Lupus model.3 Displays protective effects in particulate matter-induced acute lung injury by blocking TLR4 signaling.4
Description	CAS Number: 6501-72-0 Chemical Name: 4,5-Dihydro-3-phenyl-5-isoxazoleacetic acid Molecular weight: 205.2 Formula: C11H11NO3 Solubility: DMSO (30 mg/ml) Physical Properties: White solid Purity: 98% by HPLC