ABT-263

Overview
Catalog #	bs-82647c-5-mg
Product Name	ABT-263
Specifications
Storage Buffer	Beige solid
Storage Condition	-20°C
Target
Product Information	Potent and selective Bcl-2 family inhibitor / BH3 domain mimetic which binds to Bcl-2, Bcl-xL and Bcl-w (Ki<1 nM). A useful tool compound which has shown interesting results in various cancer clinical trials2. Synergizes with deoxyglucose and other agents, inducing apoptosis in cancer cells in a xenograft mouse model3. A novel senolytic agent, inducing apoptosis preferentially in senescent cells in a cell type-restricted manner4.
Description	CAS Number: 923564-51-6 Chemical Name: 4-[4-[[2-(4-chlorophenyl)-5,5-dimethyl-1-cyclohexen-1-yl]methyl]-1-piperazinyl]-N-[[4-[[(1R)- 3-(4-morpholinyl)-1-[(phenylthio)methyl]propyl]amino]-3-[(trifluoromethyl)sulfonyl]-phenyl]sulfonyl]-benzamide Molecular weight: 974.6 Formula: C47H55ClF3N5O6S3 Solubility: DMSO (25 mg/ml) Physical Properties: White solid Purity: 98% by HPLC (NMR Conforms)