Torin 1

Overview
Catalog #	bs-82630c-5-mg
Product Name	Torin 1
Specifications
Storage Buffer	White or off-white solid
Storage Condition	-20°C
Target
Product Information	Potent and selective ATP-competitive mTOR inhibitor, IC50=2 and 10 nM for mTORC1 and mTORC2 respectively.1,2 Active in vivo at inhibition of mTOR-mediated effects in mice (20 mg/kg).2 Induces autophagy.3 Torin 1-mediated enhancement of TFEB-mediated autophagy alleviates neuronal death in oxidative stress-induced disease models.4 Downregulates NGF expression in RSC96 cells.5
Description	CAS Number: 1222998-36-8 Chemical Name: 1-[4-[4-(1-oxopropyl)-1-piperazinyl]-3-(trifluoromethyl)phenyl]-9-(3-quinolinyl)-benzo[h]-1,6-naphthyridin-2(1H)-one Molecular weight: 607.62 Formula: C35H28F3N5O2 Solubility: DMSO (8 mg/ml) Physical Properties: White or off-white solid Purity: 98% by HPLC, NMR (Conforms)