Thiamet-G

Overview
Catalog #	bs-82589c-5-mg
Product Name	Thiamet-G
Specifications
Storage Buffer	White solid
Storage Condition	-20°C
Target
Product Information	Potent, selective inhibitor of O-GlcNAcase (Ki = 21 nM for human O-GlcNAcase). Increases levels of O-GlcNAc-modified proteins in cellular assays and in vivo. Suppresses phosphorylation of tau protein in rat cortex and hippocampus.1 Stabilizes tau against aggregation and slows neurodegeneration.2 Prevents cognitive decline and amyloid plaque formation in bigenic tau/APP mutant mice.3 Active in vivo and blood brain barrier permeable.
Description	CAS Number: 1009816-48-1 Chemical Name: (3aR,5R,6S,7R,7aR)-2-(Ethylamino)-3a,6,7,7a-tetrahydro-5-(hydroxymethyl)-5H-Pyrano[3,2-d]thiazole-6,7-diol Molecular weight: 248.30 Formula: C9H16N2O4S Solubility: DMSO (10 mg/ml) Physical Properties: Pale yellow solid Purity: 98% by TLC, NMR (Conforms)