Probucol

Overview
Catalog #	bs-82555c-1-g
Product Name	Probucol
Specifications
Storage Buffer	Off-white solid
Storage Condition	RT
Target
Product Information	Probucol (23288-49-5) is a unique antilipidemic drug which inhibits the oxidation of LDL cholesterol preventing the genesis of macrophage-derived foam cells and thus suppressing the formation of atherosclerotic vascular lesions.1 It inhibits ABCA1-mediated cholesterol efflux without influencing scavenger receptor (class B type 1)-mediated efflux.2 It enhances mitophagy and improves survival, locomotor function and dopaminergic neuron loss in zebrafish and fly models of mitochondrial damage.3 It attenuates NF-kB/NLRP3 signaling and augments Nrf-2-mediated antioxidant defense in nerve injury models.4 Improves learning and memory in aging mice.5 It protects neuronal cells against peroxide-induced damage and directly activates glutathione peroxidase-1.6
Description	CAS Number: 23288-49-5 Chemical Name: 4,4’-[(1-Methylethylidene)bis(thio)]bis[2,6-bis(1,1-dimethylethyl)-phenol Molecular weight: 516.84 Formula: C31H48O2S2 Solubility: DMSO (100 mg/ml) Ethanol (50 mg/ml) Physical Properties: Off-white solid Purity: 98% by HPLC / TLC NMR (Conforms)