Swainsonine

Overview
Catalog #	bs-82553c-1-mg
Product Name	Swainsonine
Specifications
Storage Buffer	White solid
Storage Condition	-20°C
Target
Product Information	A naturally occurring alkaloidal toxin found in locoweed. Inhibits the biosynthesis of complex glycoproteins by inhibition of Golgi mannosidase II (IC50 = 0.2 μM).1 Inhibits growth and potentiates the cytotoxic effect of taxol in hepatocellular carcinoma in vivo.2 Induces apoptosis in a variety of cell types including cerebral cortical neurons.3 Impairs adult neurogenesis and spatial learning and memory.4 Abrogation of complex glycosylation by swainsonine results in strain-and cell-specific inhibition of prion replication.5 Induces lysosomal storage disease in farm animals.6
Description	CAS Number: 72741-87-8 Chemical Name: (1S,2R,8R,8aR)-octahydro-1,2,8-indolizinetriol Molecular weight: 173.21 Formula: C8H15NO3 Solubility: DMSO (10 mg/ml) Ethanol (10 mg/ml) Water (8 mg/ml) Physical Properties: White or off-white solid Purity: 98% by TLC NMR (Conforms)