Monastrol

Overview
Catalog #	bs-82541c-5-mg
Product Name	Monastrol
Specifications
Storage Buffer	White solid
Storage Condition	-20°C
Target
Product Information	Potent, cell-permeable, small molecule inhibitor of mitosis. Monastrol-arrested cells are characterized by monopolar spindles.1 Does not affect other motor proteins or tubulin. Specifically inhibits the mitotic molecular motor kinesin Eg5, a motor protein required for spindle formation (IC50 = 14 μM).2 Mimics the effect of amyloid β on long term potentiation in a cellular model of learning and memory.3 Enhances regeneration of adult axons.4
Description	CAS Number: 254753-54-3 Chemical Name: 1,2,3,4-tetrahydro-4-(3-hydroxyphenyl)-6-methyl-2-thioxo-5-pyrimidinecarboxylic acid, ethyl ester Molecular weight: 292.35 Formula: C14H16N2O3S Solubility: DMSO (25 mg/ml) Ethanol (25 mg/ml) Physical Properties: Beige solid Purity: 98% by TLC NMR (Conforms)