BADGE

Overview
Catalog #	bs-82535c-10-mg
Product Name	BADGE
Specifications
Storage Buffer	Lyophilized or waxy solid
Storage Condition	-20°C
Target
Product Information	PPARγ antagonist with μM affinity in 3T3-L1 and 3T3-F442A preadipocyte cells. Selective over PPARδ and PPARα. Antagonizes the ability of rosiglitazone to stimulate transcriptional activity of PPARγ and abolishes its anti-inflammatory effects in a mouse model1. Induces apoptosis via PPARγ-independent mechanisms2. Induces adipogenesis in human and mouse mesenchymal stromal stem cells and in mouse 3T3-L1 preadipocytes at low nM concentrations via a PPARγ independent mechanism3. Increases osteoblastogenesis and bone mass in a mouse model4. Active in vivo.
Description	CAS Number: 1675-54-3 Chemical Name: 2,3-Bis[4-(2,3-epoxypropoxy)phenyl]propane Molecular weight: 340.41 Formula: C21H24O4 Solubility: DMSO (30 mg/ml) Ethanol (15 mg/ml) Physical Properties: Colorless low melting point solid or viscous oil depending upon temperature Purity: 95% by HPLC NMR (Conforms)