Veliparib 2HCl

Overview
Catalog #	bs-82486c-5-mg
Product Name	Veliparib 2HCl
Specifications
Storage Buffer	White solid
Storage Condition	-20°C
Target
Product Information	Potent and selective PARP-inhibitor with Ki values of 5.2 nM and 2.9 nM for PARP-1 and PARP-2, respectively.1 Restores sensitivity to DNA alkylator/methylator temozolomide in glioma cells and xenografts2, and enhances radiotherapy sensitivity in endometrial carcinoma cells3. Also improves sensitivity to DNA replication inhibitor cisplatin in human oral carcinoma cells.4
Description	CAS Number: 912445-05-7 Chemical Name: 2-[(2R)-2-Methyl-2-pyrrolidinyl]-1H-benzimidazole-7-carboxamide dihydrochloride Molecular weight: 317.22 Formula: C13H16N4O·2HCl Solubility: DMSO (30 mg/ml) Water (40 mg/ml) Physical Properties: White solid Purity: 98% by TLC, NMR (Conforms)