ß-Lapachone

Overview
Catalog #	bs-82478c-5-mg
Product Name	ß-Lapachone
Specifications
Storage Buffer	White solid
Storage Condition	-20°C
Target
Product Information	A naturally occurring quinone found in the bark of the Lapacho tree (Tabebuia avellanedae). A novel DNA topoisomerase I inhibitor which unlike camptothecin does not stabilize the cleavable complex indicating a novel mode of action.1 Induces apoptosis in a number of cancer cell lines.2 In cancer cells overexpressing NAD(P)H:quinone oxidoreductase, reduction of -lapachone leads to futile cycling between quinone and hydroquinone forms3 resulting in the production of reactive oxygen species4. Suppresses radiation-induced activation of NFB.5
Description	CAS Number: 4707-32-8 Chemical Name: 3,4-dihydro-2,2-dimethyl-2H-naphtho[1,2-b]pyran-5,6-dione Molecular weight: 242.27 Formula: C15H14O3 Solubility: DMSO (35 mg/ml) Ethanol (15 mg/ml Physical Properties: Orange solid Purity: 98% by TLC NMR (Conforms)