Ansamitocin P3

Overview
Catalog #	bs-82432c-1-mg
Product Name	Ansamitocin P3
Specifications
Storage Buffer	White solid
Storage Condition	-20°C
Target
Product Information	Ansamitocin P3 (66547-09-9) is a fungal metabolite from Actinosynnema pretiosum which binds to the phomopsin A/rhizoxin site on tubulin1,2. Ansamitocin P3 is a maytansine analog which displays potent cytotoxicity against various human tumor cell lines2,3. Maytansine and its analogs cause extensive disassembly of microtubules and totally prevent tubulin spiralization4.
Description	CAS Number: 66547-09-9 Chemical Name: Molecular weight: 635.16 Formula: C32H43ClN2O9 Solubility: DMSO (50 mg/ml) Ethanol (30 mg/ml) Physical Properties: Yellow solid Purity: >90% by TLC [1:9 CH3OH:CH2Cl2, Rf = 0.54] remainder is P-1, P-2 and P-4. NMR (Conforms)