Gambogic acid

Overview
Catalog #	bs-82430c-5-mg
Product Name	Gambogic acid
Specifications
Storage Buffer	Orange solid
Storage Condition	-20°C
Target
Product Information	Induces apoptosis in a variety of cell lines acting as an antagonist of Bcl-2 family proteins (IC50 < 1 μM)1, however additional targets may contribute to its cytotoxicity. It suppresses cancer invasion and migration by inhibiting TGFβ1-induced epithelial-to-mesenchymal transition.2 Potentiates the chemosensitivity of cancer cells to other agents.3 Down-regulates surviving, reversing docetaxel resistance in cancer cells.4
Description	CAS Number: 2752-65-0 Chemical Name: Molecular weight: 628.75 Formula: C38H44O8 Solubility: DMSO (45 mg/ml) Ethanol (50 mg/ml) Physical Properties: Orange solid Purity: 98% by TLC, NMR (Conforms)