Lenalidomide

Overview
Catalog #	bs-82415c-100-mg
Product Name	Lenalidomide
Specifications
Storage Buffer	Yellow solid
Storage Condition	RT
Target
Product Information	Thalidomide analog which, like thalidomide,1 binds to cereblon which is the substrate recognition component of a cullin-dependent ubiquitin ligase and inhibits its autoubiquitination activity2. Induces degradation of T-cell repressors Ikaros (IKZF1) and Aiolos (IKZF3) leading to T cell activation2. Selective inhibition of IKZF1 and IKZF3 in multiple myeloma cells results in cell death3,4. Cell permeable. Caution: Teratogenic
Description	CAS Number: 191732-72-6 Chemical Name: (R,S)-3-(4-Amino-1-oxo-3H-isoindol-2-yl)piperidine-2,6-dione Molecular weight: 259.26 Formula: C13H13N3O3 Solubility: DMSO (30 mg/ml) Physical Properties: White solid Purity: 98% by TLC, NMR (Conforms)