Doramapimod

Overview
Catalog #	bs-82403c-5-mg
Product Name	Doramapimod
Specifications
Storage Buffer	Off-white solid
Storage Condition	-20°C
Target
Product Information	Potently and selectively inhibits p38 MAPK by simultaneously binding to the ATP-binding domain and an allosteric site.1 (IC50=18 nM). Displays anti-inflammatory activity2 but differential effects on inflammatory genes3. Cell permeable.
Description	CAS Number: 285983-48-4 Chemical Name: 1-[5-tert-Butyl-2-(4-methylphenyl)pyrazol-3-yl]-3-[4-(2-morpholin-4-ylethoxy)naphthalene-1-yl]urea Molecular weight: 527.66 Formula: C31H37N5O3 Solubility: DMSO (50 mg/ml) Ethanol (30 mg/ml) Physical Properties: White or off-white solid Purity: 98% by TLC, NMR (Conforms)