Bexarotene

Overview
Catalog #	bs-82399c-10-mg
Product Name	Bexarotene
Specifications
Storage Buffer	White solid
Storage Condition	-20°C
Target
Product Information	A highly potent and selective retinoid X receptor (RXR) agonist (EC50=28, 25, 20 nM for RXRα, β, γ respectively)1. Clinically useful antineoplastic agent for cutaneous T-cell lymphoma2 Causes complete regression of mammary carcinoma3. Bexarotene significantly increases clearance of soluble β-amyloid in a mouse Alzheimer′s model and increases cognitive ability4. Reverses apoE4-driven brain pathology and behavioral deficits in vivo5.
Description	CAS Number: 153559-49-0 Chemical Name: 4-[1-(5,6,7,8-Tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl)ethenyl]benzoic acid Molecular weight: 348.49 Formula: C24H28O2 Solubility: DMSO (60 mg/ml) Ethanol (10 mg/ml) Physical Properties: White solid Purity: 98% by TLC, NMR (Conforms)