Axitinib

Overview
Catalog #	bs-82398c-10-mg
Product Name	Axitinib
Specifications
Storage Buffer	Off-white solid
Storage Condition	-20°C
Target
Product Information	Potent inhibitor of VEGFR-2, -3, and -1, IC50 = 0.2, 0.1-0.3, and 1.2 nM respectively1 displaying minimal activity against a panel of ~100 protein kinases. Inhibits angiogenesis and vascular permeability.2 Also inhibits BCR-ABL1 (T315I) with high potency, Ki = 149 pM for autophosphorylated ABL1 (T315I).3 Inhibits proliferation of Ba/F3 cells expressing BCR-ABL1 (T315I). Clinically useful anticancer agent.4
Description	CAS Number: 319460-85-0 Chemical Name: N-Methyl-[[3-[(1E)-2-(2-pyridinyl)ethenyl]-1H-indazol-6-yl]thio]benzamide Molecular weight: 386.47 Formula: C22H18N4OS Solubility: DMSO (30 mg/ml) Physical Properties: White solid Purity: 99% by HPLC, NMR (Conforms)